克罗米酚对男性低促性腺素性功能减退症有效性

纽约（费希尔社肥胖版）1年末四日另据：据发表在12年末选集的《生育与不育》杂志的一项报告说明克罗米酮类对部分低促性腺素性动态大不如前的成年病变不利。来自伯明翰新泽西大学的该报告的第一作者Scott J. Whitten哈佛大学在接受费希尔通讯社美联社时话说：“原发性或获得性HH病变在接受侵害性更大和更为昂贵的病患（例如注射促性腺激素类）前来进行4个年末的克罗米酮类试验性病患是不利的。”Whitten哈佛大学和室友研究了克罗米酮类对10名HH成年病变（HH是所致成年不育的少见因素）是否是有效。报告称克罗米酮类病患1年后，4名卡尔曼(氏)症病变中只有一名病变的精子浓度增高而全垂体动态大不如前症病变的精子缺乏呕吐均没有人得到改善。相反，该报告说明3名成年发病的原发性HH成年病变经过3个年末克罗米酮类的病患精子浓度有了明显增高。目前为止该组病变已为两名以后了生育能力。Whitten哈佛大学话说：“除非对克罗米酮类病患没有人化学反应，我们不会因为病症停顿对病变使用该药物。”最后作者论述话说：“因为条件有限，对HH病变促性腺激素抑制剂和克罗米酮类的随机研究难以来进行，然而透过多复刻版的完全符合自由选择标准对病变来进行分级可能帮助进一步验证克罗米酮类以后成年低生育能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

总编辑：蓝色幻想

总编辑： 张靖